[Edarta]

At the moment of writing, I run the I.S.S. Zarathustra with [EPG] and [CtrlX] modifier consoles resulting in Drain,CtrlX,EPG values of 130,317,377. This makes a lovely pulling Gravity Well pulling Borg Spheres from behind my vessel straight into my front arc and collecting Terran Frigates from quite far away into my playing ground. The rather low drain is not so good for a basic Polaron outfit and I may look into replacing the Energy Siphon by a Sub Space Vortex.

Alternate Weapon Loadouts
As the ship does not rely on boosting weapon damage for a certain type of damge, the Fleet Polaron and R&D Polaron Omnidirectional Beam can be replaced by something different w/o remorse. I just look into Procs and triggers.
I have no new ISA monster dps log to tell peak performance for the various loadouts. 50+ K dps became a just usual outcome und the vessel is tanky.

Plasma Weapons
Bad News
Plasma Fire does not benefit from Exotic Particle Generators. If it ever has, now even the Tooltip avoids mentioning the word "exotic".
Good News
The Experimental Romulan Plasma Beam Array does not drain weapon energy. This maintains the [Amp] boost of my Warp Core.
Plasma Fire apparently triggers the Atrophied Defenses from the Temporal Agent Specialization. It and should also benefit from the Entropic Amplification. 

I run Romulan Rep Store Weapons - these offer another Proc, reducing my opponent's damage resistance.

Agony Phasers
These come with Disable and Dot Procs. As Plasma weapons they should trigger Atrophied Defenses and a high CtrlX value should help overcome resistances against disabling.

My Relatively Controlled Test Environment
I found the Archer System Patrol at Elite Difficulty quite useful to observe how opponents are debuffed (elite Tholians just last longer) and how the ship behaves in general.